Figure 8.

Effect of AMP analogues on TRPM2 activation by ADPR (1). Maximum outward currents were recorded as outlined in the Experimental Section. Pipet solutions contained either no nucleotide and 100 μM of 1 alone or in combination with the indicated ADPR analogue. Data are shown as mean ± SEM (number of experiments denoted in or on top of the bar) and were analyzed by a nonparametric one-way ANOVA (Kruskal–Wallis test) followed by comparison against control (100 μM of 1) using Dunn’s correction for multiple testing. Results significantly different from control (p < 0.05) are indicated by asterisks.