Figure 9.

Effect of terminal ribose-modified ADPR analogues on TRPM2 activation by ADPR (1). Maximum outward currents were recorded as outlined in the Experimental Section. Pipet solutions contained either no nucleotide or 100 μM of 1 alone or in combination with the indicated ADPR analogue. 8-Br-ADPR (4) was included as inhibitor control. Data are shown as mean ± SEM (number of experiments denoted in or on top of the bar) and were analyzed by a one-way ANOVA followed by comparison against control (100 μM of 1) using Dunn’s correction for multiple testing. Results significantly different from control (p < 0.05) are indicated by asterisks.