Scheme 1. Synthesis of 8-Substituted ADPR Analogues.
Reagents and conditions: (i) NADase, Tris buffer (0.1 M, pH 7.2), rt, 92%; (ii) Br2, NaOAc buffer (0.5 M, pH 4), rt, 25%; (iii) Cs2CO3, Pd(OAc)2, TPPTS, X(BOH)2, MeCN–H2O, 125 °C, 5 min, 12–25%.
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