Scheme 3. Synthesis of 8-NH2–ADPR.
Reagents and conditions: (i) morpholine, dipyridyl disulfide, PPh3, DMSO, rt, 1 h then β-NMN+, MgSO4, 0.2 M MnCl2, 13%; (ii) NADase, Tris buffer (0.1M, pH 7.3), rt, 40%.
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