Scheme 8. Synthesis of ATPR.
Reagents and conditions: (i) β-NMN+, MgCl2 (1M), HEPES (2M), EDC, 24 h, rt, 38%; (ii) Aplysia cyclase, HEPES (25 mM, pH 7.5), 3 days, rt, 39%; (iii) HEPES (25 mM, pH 7.5), reflux, 1 h, 54%.
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