Table 5. Z-statistics for MRI measures in regression models for the clinical outcomes, controlling for change in the clinical outcome, controlling for age, education, gender, APOE-4, and intracranial volume.
| Clinical outcome | Ventricular Volume | Brain volume | Hippocampal Volume | Entorhinal Cortex Volume |
|---|---|---|---|---|
| ADAS-Classic | 2.75 | −3.46 | −5.76 | −6.00 |
| ADAS-Modified | 2.58 | −3.64 | −6.78 | −7.07 |
| ADAS-Rasch | 2.69 | −3.22 | −5.20 | −4.45 |
| ADAS-Tree | 2.53 | −3.64 | −7.46 | −7.40 |
| ADAS-Bifactor | 2.93 | −3.16 | −5.79 | −5.57 |
| ADAS-Plus EF | 3.01 | −3.41 | −5.94 | −5.35 |
| ADAS-Plus EF & FA | 3.98 | −4.36 | −6.53 | −5.41 |