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C-furSema C-terminal arginine contributes to high affinity binding to Nrp. A) An alanine scan of the C-terminus of C-furSema was performed. The ability of C-furSema and mutants to inhibit AP-VEGF-A binding to Nrp1 was determined. B) Inhibition curves were utilized to determine peptide potency (IC50), with a significant decrease only observed with the C-terminal arginine mutant.
