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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Clin Gastroenterol Hepatol. 2013 Apr 16;11(9):10.1016/j.cgh.2013.03.035. doi: 10.1016/j.cgh.2013.03.035

Table 2.

Predictors of 7-Day Mortality on Simple and Multiple Logistic Regression in the IU–ICU and Penn–ICU Cohorts

Variables from ICU day 1 OR 95% CI P
IU–ICU cohorta
 Simple logistic regression
  MELDb 1.13 1.09–1.18 <.001
  Mechanical ventilationb 3.3 1.7–6.7 .001
  Renal replacement therapyb 2.4 1.1–5.2 .03
  Vasopressor requirementb 4.7 2.4–9.3 <.001
  Mean arterial pressure 0.95 0.92–0.95 <.001
  Serum sodium 0.94 0.9–0.99 .02
  Serum bicarbonate 0.93 0.87–0.99 .03
  White blood cell count 1.06 1.01–1.11 .01
  ICU admission within 3 d of hospitalizationb 0.3 0.14–0.68 .004
  ICU admission for gastrointestinal bleedingb 0.5 0.22–1.12 .09
 Multiple logistic regression
  MELDb 1.13 1.07–1.2 <.001
  Mechanical ventilation 5.7 2.3–14.1 <.001
Penn–ICU cohortc
 Simple logistic regression
  MELDb 1.06 1.03–1.09 <.001
  Mechanical ventilationb 3.16 1.78–5.59 <.001
  Shock 4.35 1.91–9.90 <.001
  Vasopressor requirementb 2.63 1.33–5.17 .005
  Serum lactate 1.17 1.09–1.26 <.001
  APACHE III 1.03 1.02–1.04 <.001
  Acute kidney injury 2.60 1.17–5.76 .02
  Renal replacement therapyb 0.52 0.30–0.91 .02
  ICU admission within 3 d of hospitalizationb 0.42 0.21–0.83 .013
  Receipt of blood products 0.86 0.81–0.91 <.001
  ICU admission for gastrointestinal bleedingb 0.33 0.18–0.59 <.001
 Multiple logistic regression
  MELDb 1.08 1.03–1.13 .001
  Shock 4.81 1.56–14.89 .006
  Serum lactate 1.14 1.04–1.25 .005
  Receipt of blood products 0.83 0.77–0.90 <.001
  Renal replacement therapy 0.17 0.06–0.43 <.001

NOTE. Variables achieving a P value less than 0.1 on simple logistic regression were included in the multiple logistic regression.

a

Nonpredictive factors in the IU–ICU cohort included the following: age, sex, etiology of liver disease, presence of ascites, hepatic encephalopathy or underlying malignancy, serum albumin, sepsis, and being listed for liver transplant.

b

Common predictors.

c

Nonpredictive factors in the Penn–ICU cohort included the following: age, sex, race, etiology of liver disease, underlying malignancy, presence of sepsis, being listed for liver transplant, hepatic encephalopathy, ascites, serum sodium, white blood cell count, and serum albumin.