Table 3.
The area occupied by acetylcholine axons in the hippocampus and cortex of adult mice
| Hippocampus |
|||||||
|---|---|---|---|---|---|---|---|
| Treatment | Sex | CA1 | CA1SR | CA3 | CA3SR | DGG | DGM |
| Saline | Males | 2,624.8 ± 1,502.2 | 2,026.0 ± 798.0 | 2,780.2 ± 1,287.5 | 2,409.3 ± 905.3 | 2,292.4 ± 1,025.5 | 3,074.0 ± 1,213.9 |
| Methamphetamine | Males | 1,951.2 ± 544.8 | 2,184.6 ± 290.5 | 2,513.1 ± 516.7 | 2,521.4 ± 454.2 | 2,521.2 ± 489.8 | 3,861.7 ± 403.1 |
| Saline | Females | 3,454.1 ± 1,524.7 | 3,360.1 ± 1,496.9 | 4,594.2 ± 1,675.6 | 4,139.3 ± 1,557.1 | 3,802.9 ± 1,328.5 | 4,067.6 ± 1,428.6 |
| Methamphetamine | Females | 3,301.0 ± 587.1 | 2,942.0 ± 592.0 | 3,833.2 ± 715.5 | 3,464.2 ± 708.2 | 2,763.7 ± 755.8 | 3,689.8 ± 536.8 |
| Cortex |
|||||||
|---|---|---|---|---|---|---|---|
| Treatment | Sex | EhC | Lateral EhC | Motor | Piriform | 1° Sensory | 2° Sensory |
| Saline | Males | 2,253.7 ± 1,069.1 | 3,196.7 ± 1,476.4 | 289.7 ± 286.8 | 3,377.1 ± 1,395.5 | 790.4 ± 286.6 | 261.9 ± 247.2 |
| Methamphetamine | Males | 4,781.4 ± 1,963.6 | 5,814.0 ± 1,839.6 | 1,946.8 ± 599.6 | 4,971.8 ± 1,367.8 | 2,141.9 ± 748.8 | 4,718.3 ± 2,367.4 |
| Saline | Females | 3,561.8 ± 1,297.3 | 3,599.2 ± 1,441.9 | 1,426.6 ± 747.3 | 4,404.9 ± 1,248.8 | 1,889.7 ± 1,140.4 | 2,635.4 ± 1,556.7 |
| Methamphetamine | Females | 3,709.0 ± 684.3 | 4,876.1 ± 742.5 | 1,744.1 ± 695.8 | 5,638.3 ± 670.1 | 2,255.9 ± 904.9 | 1,784.2 ± 547.1 |
Data expressed as mean area occupied by choline acetyltransferase immunoreactivity (μM2) ± SEM. n = 4–5 mice per treatment per sex. SR, stratum radiatum; DGG, dentate gyrus granule layer; DGM, dentate gyrus molecular layer; EhC, entorhinal cortex.