. Author manuscript; available in PMC: 2013 Dec 27.

Published in final edited form as: Nat Commun. 2013;4:1973. doi: 10.1038/ncomms2973

Table 3.

Effect size for HDL-C (mg/dl) based on haplotypes reconstructed using tag SNPs from our prior work in families⁽¹³⁾.

Haplotype^*	Frequency in BioVU cohort	Association with HDL-C (p-value^**)	Haplotype copy number (mean ± SD, mg/dl)
Haplotype^*	Frequency in BioVU cohort	Association with HDL-C (p-value^**)	0	1	2
H1	0.29	0.7273	52.80 ± 16.47	53.02 ± 16.58	51.92 ± 14.76
H2	0.27	0.2699	52.65 ± 15.68	52.38 ± 17.34	56.51 ± 15.47
H3	0.22	0.3366	52.42 ± 16.26	53.46 ± 16.85	53.35 ± 14.00
H4	0.12	0.01704	53.47 ± 16.30	50.85 ± 16.76	48.03 ± 12.52
H5	0.07	0.8467	52.80 ± 16.33	52.83 ± 16.85	54.30 ± 15.76

TagSNPs used to defined haplotype from 5′ to 3′: rs806370|rs806369|rs1049353|rs12720071|rs806368|rs806366

^**

An additive model was used to calculate P-values in PLINK. P-values less than 0.05 are highlighted in red.