Table 5. Association analysis of the selected tSNPs, diplotypes in CDK1 in relation to event-free survival of breast cancer patients (n=1005).
| Parameter | No. | Noevent (%) | Log-rank P value | HR (95%CI) | P value | aHR (95%CI)* | P value* |
|---|---|---|---|---|---|---|---|
| CDK1 tSNPs | |||||||
| rs2448343 | |||||||
| GG | 665 | 107 (16.09%) | 0.241 | ||||
| AG | 305 | 39 (12.79%) | 0.762 (0.528-1.100) | 0.147 | 0.760 (0.523-1.106) | 0.152 | |
| AA | 35 | 7 (20.00%) | 1.293 (0.602-2.778) | 0.510 | 1.262 (0.585-2.719) | 0.553 | |
| (AA+AG) vs. GG (dominant model) | 0.813 (0.576-1.149) | 0.241 | 0.811 (0.570-1.153) | 0.243 | |||
| AA vs. (AG+GG) (recessive model) | 1.399 (0.655-2.987) | 0.386 | 1.370 (0.640-2.9330 | 0.417 | |||
| rs3213048 | |||||||
| TT | 404 | 53 (13.12%) | 0.072 | ||||
| CT | 460 | 83 (18.04%) | 1.429 (1.013-2.018) | 0.042 | 1.450 (1.019-2.063) | 0.039 | |
| CC | 141 | 17 (12.06%) | 0.954 (0.552-1.647) | 0.865 | 0.863 (0.485-1.536) | 0.617 | |
| (CC+CT) vs. TT (dominant model) | 1.318 (0.944-1.839) | 0.104 | 1.307 (0.929-1.839) | 0.124 | |||
| CC vs. (CT+TT) (recessive model) | 0.779 (0.471-1.290) | 0.332 | 0.701 (0.410-1.197) | 0.193 | |||
| rs3213067 | |||||||
| AA | 715 | 109 (15.24%) | 0.963 | ||||
| GA | 254 | 39 (15.35%) | 1.030 (0.715-1.485) | 0.873 | 1.047 (0.718-1.525) | 0.813 | |
| GG | 36 | 5 (13.89%) | 0.909 (0.371-2.229) | 0.835 | 0.970 (0.395-2.381) | 0.946 | |
| (GG+GA) vs. AA (dominant model) | 1.015 (0.715-1.440) | 0.934 | 1.037 (0.724-1.485) | 0.844 | |||
| GG vs. (GA+AA) (recessive model) | 0.902 (0.370-2.200) | 0.821 | 0.958 (0.392-2.342) | 0.926 | |||
| rs1871446 | |||||||
| CC | 789 | 121 (15.34%) | 0.001 | ||||
| TC | 205 | 27 (13.17%) | 0.831 (0.547-1.261) | 0.384 | 0.777 (0.507-1.190) | 0.246 | |
| TT | 11 | 5 (45.45%) | 4.323 (1.763-10.599) | 0.001 | 5.795 (2.317-14.492) | 0.0002 | |
| (TT+TC) vs. CC (dominant model) | 0.951 (0.644-1.404) | 0.064 | 0.905 (0.608-1.348) | 0.623 | |||
| TT vs. (TC+CC) (recessive model) | 4.482 (1.834-10.954) | 0.001 | 5.087 (2.071-12.497) | 0.0004 | |||
| rs10711 | |||||||
| GG | 408 | 59 (14.46%) | 0.981 | ||||
| TG | 441 | 70 (15.87%) | 1.035 (0.731-1.465) | 0.846 | 1.098 (0.768-1.570) | 0.608 | |
| TT | 156 | 24 (15.38%) | 1.011 (0.628-1.627) | 0.965 | 1.193 (0.734-1.940) | 0.477 | |
| (TT+TG) vs. GG (dominant model) | 1.029 (0.742-1.426) | 0.865 | 1.121 (0.802-1.568) | 0.503 | |||
| TT vs. (TG+GG) (recessive model) | 0.992 (0.641-1.535) | 0.972 | 1.136 (0.727-1.774) | 0.577 | |||
| rs1060373 | |||||||
| GG | 807 | 124 (15.37%) | 0.923 | ||||
| AG | 192 | 28 (14.58%) | 0.974 (0.646-1.468) | 0.900 | 0.944 (0.621-1.434) | 0.787 | |
| AA | 6 | 1 (16.67%) | 1.460 (0.204-10.431) | 0.706 | 1.427 (0.199-10.245) | 0.724 | |
| (AA+AG) vs. GG (dominant model) | 0.985 (0.658-1.476) | 0.943 | 0.955 (0.632-1.443) | 0.828 | |||
| AA vs. (AG+GG) (recessive model) | 1.467 (0.206-10.468) | 0.702 | 1.443 (0.201-10.344) | 0.715 | |||
| CDK1 diplotypes | |||||||
| GCACG/GTACG | 181 | 33 (18.23%) | \ | ||||
| GCACG/GCACG | 113 | 13 (11.50%) | \ | 0.601 (0.316-1.143) | 0.121 | 0.496 (0.250-0.986) | 0.046 |
| GCACG/ATATT | 98 | 22 (22.45%) | \ | 1.188 (0.811-1.741) | 0.377 | 1.194 (0.814-1.752) | 0.345 |
| GTACG/GTGCT | 73 | 10 (13.70%) | \ | 0.663 (0.402-1.094) | 0.108 | 0.710 (0.430-1.172) | 0.180 |
| GCACG/GTGCT | 68 | 8 (11.76%) | \ | 0.598 (0.276-1.295) | 0.192 | 0.664 (0.305-1.444) | 0.301 |
| GTACG/GTACG | 66 | 8 (12.12%) | \ | 0.548 (0.253-1.187) | 0.127 | 0.556 (0.255-1.213) | 0.140 |
| GTACG/ATATT | 51 | 5 (9.80%) | \ | 0.471 (0.242-0.917) | 0.027 | 0.470 (0.241-0.915) | 0.026 |
| GCACG/ATACT | 47 | 7 (14.89%) | \ | 0.678 (0.380-1.208) | 0.187 | 0.644 (0.361-1.151) | 0.138 |
| GTACG/ATACT | 42 | 9 (21.43%) | \ | 1.139 (0.676-1.918) | 0.625 | 1.011 (0.599-1.705) | 0.968 |
| GTGCT/ATATT | 30 | 4 (13.33%) | \ | 0.715 (0.343-1.490) | 0.371 | 0.641 (0.307-1.333) | 0.236 |
| GTGCT/ATACT | 27 | 3 (11.11%) | \ | 0.524 (0.227-1.210) | 0.131 | 0.501 (0.217-1.157) | 0.106 |
| GTGCT/GTGCT | 25 | 1 (4.00%) | \ | 0.205 (0.050-0.838) | 0.027 | 0.192 (0.047-0.785) | 0.022 |
| ATATT/ATACT | 13 | 2 (15.38%) | \ | 0.800 (0.292-2.196) | 0.665 | 0.805 (0.293-2.213) | 0.675 |
| ATATT/ATATT | 7 | 3 (42.86%) | \ | 3.022 (1.309-6.975) | 0.009 | 3.988 (1.712-9.290) | 0.001 |
| else | 164 | 25 (15.24%) | \ | 0.810 (0.560-1.171) | 0.262 | 0.770 (0.532-1.114) | 0.165 |
* Adjusted for age, BMI, age at menarche, age at first full-term pregnancy, menopause status, and family history of cancer in first-degree relatives.
Bold values indicate a statistical significance at 0.05 level.