Mimivirus, a giant virus naturally infecting free-living amoebae. (A) Mimivirus and A. polyphaga, as seen by scanning electron microscopy. Bar, 1 μm. (B) Mimivirus. Negative coloration, as seen by transmission electron microscopy. Bar, 200 nm. (C) Mimivirus within A. polyphaga in a laboratory infection, as seen by transmission electron microscopy. Bar, 2 μm. Magnifications, ×3,375 (A), ×33,750 (B), and 3,000 (C). Reprinted with permission from B. La Scola (A and C) and N. Aldrovandi (B).