Table 3. QAlb * by number of ApoE4, ApoE3, ApoE2 alleles and type of dementia under the assumption of dominant and additive genetic models.
| Dominant genetic model | Additive genetic model | |||||||
| Mean QAlb (95% Confidence Intervall)* | Mean QAlb (95% Confidence Intervall)* | |||||||
| E4 vs. no E4 | ≥one E4 allele | No E4 allele | P value ** | E4 as risk allele | E4/E4 | One E4 allele | No E4 | P value ** |
| All cases (n = 520) | 6.18 (5.81–6.58) | 6.21 (5.93–6.50) | 0.920 | All cases (n = 520) | 5.70 (4.94–6.58) | 6.28 (5.86–6.72) | 6.21 (5.93–6.50) | 0.599 |
| CJD (n = 350) | 5.76 (5.28–6.28) | 6.13 (5.81–6.47) | 0.427 | CJD (n = 350) | 5.72 (4.26–7.68) | 5.76 (5.27–6.31) | 6.13 (5.81–6.47) | 0.723 |
| AD (n = 71) | 6.60 (5.79–7.51) | 5.76 (4.87–6.81) | 0.254 | AD (n = 71) | 5.38 (4.17–6.95) | 6.98 (6.03–8.08) | 5.76 (4.87–6.81) | 0.222 |
| VD (n = 99) | 6.75 (6.00–7.59) | 6.77 (6.16–7.44) | 0.926 | VD (n = 99) | 6.11 (4.90–7.60) | 6.93 (6.04–7.95) | 6.77 (6.16–7.44) | 0.813 |
| E3 vs. no E3 | ≥one E3 allele | No E3 allele | P value ** | E3 as risk allele | E3/E3 | One E3 allele | No E3 | P value ** |
| All cases (n = 520) | 6.17 (5.93–6.41) | 6.56 (5.78–7.46) | 0.234 | All cases (n = 520) | 6.19 (5.89–6.51) | 6.13 (5.78–6.51) | 6.56 (5.78–7.46) | 0.813 |
| CJD (n = 350) | 5.97 (5.70–6.26) | 7.18 (5.89–8.76) | 0.035 | CJD (n = 350) | 6.06 (5.72–6.43) | 5.80 (5.36–6.27) | 7.18 (5.89–8.76) | 0.086 |
| AD (n = 71) | 6.27 (5.60–7.03) | 6.35 (4.93–8.17) | 0.921 | AD (n = 71) | 5.87 (4.91–7.03) | 6.56 (5.66–7.61) | 6.35 (4.93–8.17) | 0.567 |
| VD (n = 99) | 6.89 (6.37–7.45) | 5.74 (4.72–6.97) | 0.274 | VD (n = 99) | 6.97 (6.25–7.78) | 6.79 (6.06–7.61) | 5.74 (4.72–6.97) | 0.490 |
| E2 vs. no E2 | ≥one E2 allele | No E2 allele | P value ** | E2 as risk allele | E2/E2 | E2 | No E2 | P value ** |
| All cases (n = 520) | 6.56 (5.93–7.27) | 6.14 (5.90–6.38) | 0.202 | All cases (n = 520) | 7.85 (5.00–12.34) | 6.48 (5.84–7.20) | 6.14 (5.90–6.38) | 0.198 |
| CJD (n = 350) | 6.62 (5.83–7.50) | 5.93 (5.65–6.22) | 0.126 | CJD (n = 350) | 9.29 (6.25–13.82) | 6.45 (5.66–7.34) | 5.93 (5.65–6.22) | 0.095 |
| AD (n = 71) | 7.51 (5.00–11.27) | 6.19 (5.56–6.88) | 0.274 | AD (n = 71) | - | 7.51 (5.00–11.27) | 6.19 (5.56–6.88) | 0.277 |
| VD (n = 99) | 6.04 (5.05–7.21) | 6.90 (6.36–7.47) | 0.155 | VD (n = 99) | 4.00 | 6.04 (5.05–7.21) | 6.90 (6.36–7.47) | 0.250 |
*Back-transformed means and 95% confidence intervals of the natural logarithm of QAlb.
**ANCOVA adjusted for age and sex.