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. 2013 Dec 27;8(12):e84634. doi: 10.1371/journal.pone.0084634

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© 2013 Suárez-Fariñas et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. Differences in gene expression in naïve, IL-23, IL-23+IMO-3100 and IL-23+IMO-8400 treated mice were analyzed using principal component analysis. Partial normalization of gene expression patterns in the IL-23-induced mouse model was seen following treatment with TLR antagonists, with IMO-8400 exerting a slightly greater effect. B. IMO-8400 modulated 10% more of the IL-23 altered genes compared to IMO-3100, indicating additive effects of TLR8 antagonism in addition to TLR7 and 9. C. Shifts in gene expression profiles for IL-23 treated mice towards naïve mice following treatment with TLR antagonists are displayed in heatmap. Of the genes that shifted towards recovery with TLR antagonism, a greater proportion consisted of shared human and mouse genes rather than those that were unique murine genes.