Table 1. GSEA analysis for the IL23-induced phenotype in mice versus psoriasis transcriptomes in human.
| Psoriasis Transcriptomes | Up |
Down |
Reference | |||||
|---|---|---|---|---|---|---|---|---|
| Size | ES 1 | NES 2 | Size | ES | NES | CS 3 | ||
| Gudjonsson ’09 (LSvsNL) | 425 | 0.71 | 2.41 | 214 | -0.58 | -2.43 | 0.65 | [52] |
| Gudjonsson ’10 (LSvsNormal) | 482 | 0.70 | 2.43 | 336 | -0.59 | -2.54 | 0.64 | [37] |
| MAD5 | 579 | 0.68 | 2.37 | 390 | -0.58 | -2.57 | 0.63 | [36] |
| MAD3 | 899 | 0.66 | 2.33 | 608 | -0.59 | -2.70 | 0.63 | [36] |
| Yao’08 | 820 | 0.68 | 2.40 | 730 | -0.55 | -2.59 | 0.62 | [40] |
| Suárez-Fariñas ’10 | 500 | 0.67 | 2.34 | 633 | -0.52 | -2.43 | 0.60 | [38] |
| NGS (Jabbari/SF’12) | 895 | 0.62 | 2.15 | 748 | -0.58 | -2.77 | 0.60 | [53] |
| Suárez-Fariñas + | 1362 | 0.58 | 2.04 | 949 | -0.53 | -2.54 | 0.55 | [39] |
| Zhou ‘03 | 220 | 0.68 | 2.27 | 344 | -0.42 | -1.88 | 0.55 | [54] |
| Methylation in Psoriasis (LSvsNormal) | 379 | -0.65 | -2.22 | 457 | 0.34 | 1.55 | -0.49 | [55] |
Size indicates the number of genes in each transcriptome
1 ES = enrichment score
2 NES = normalized enrichment score
3 CS = connectivity core, calculated as ½(ES(Up)-ES(Down))