55 |
Open, randomized, prospective |
40 entero-ReA (Yersinia, Salmonella, Campylobacter) |
No treatment versus antibacterial agents (pivampicilin, pivmecillinam, doxycycline, erythromycin, co-trimoxazole, cinxacin) |
No difference in duration of arthritis, grade of inflammation, number of joints involved, laboratory tests |
123 |
Open |
108 enterocolitis |
65 treated with antibacterials (9 days) (ciprofloxacin, norfloxacin, doxycycline, co-trimoxazole, pivmecillinam- pivampicillin) |
No effects of antibiotics on prevention of development of arthritis |
11 |
Retrospective |
224 episodes of genitourinary tract infections (60 ReA patients with urogenital infections) |
59 episodes, no treatment; 97 episodes, penicillin treatment; 68 episodes, erythromycin or tetracyclin therapy for at least 1 day |
37% of those not treated or treated with penicillin developed ReA, compared with 10% of those treated with erythromycin or tetracycline |