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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Genes Brain Behav. 2013 Aug 29;12(7):723–731. doi: 10.1111/gbb.12071

Figure 2. Chronic lithium treatment of adult or adolescent Fmr1 KO mice ameliorates temporal order memory deficits.

Figure 2

Adult and adolescent male Fmr1 KO and WT mice were treated with lithium for 4 weeks prior to testing. (A) Times spent exploring the first object presented (Object 5) and the object most recently explored (Object 7). (Student's t-test; *p<0.05 compared to time spent with Object 7; WT no treatment: n=20, t(38)=4.82, p<0.05; WT adult lithium treatment: n=10, t(18)=2.74, p<0.05; WT adolescent lithium treatment: n=9, t(12)=4.56, p<0.05; Fmr1 KO no treatment: n=20, t(38)=3.16, p<0.05; Fmr1 KO adult lithium treatment: n=9, t(16)=6.21, p<0.05; Fmr1 KO adolescent lithium treatment: n=9, t(16)=2.38, p<0.05). (B) Exploration ratio. (two-way ANOVA (genotype x treatment) followed by post hoc Bonferroni's multiple comparison test; F(2,75)=27.48, p<0.05; **p<0.05 compared to untreated WT mice; *p<0.05 compared to same genotype without treatment).