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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Genes Brain Behav. 2013 Aug 29;12(7):723–731. doi: 10.1111/gbb.12071

Figure 3. Chronic lithium treatment of adult or adolescent Fmr1 KO mice alleviates spatial processing impairments in Fmr1 KO mice.

Figure 3

Adult and adolescent male Fmr1 KO and WT mice were treated with lithium for 4 weeks prior to testing. (A) Exploration ratio in the coordinate spatial processing task (two-way ANOVA (genotype x treatment) followed by post hoc Bonferroni's multiple comparison test; F(2,68)=10.68, p<0.05). (B) Exploration ratio in the categorical spatial processing task (two-way ANOVA (genotype x treatment) followed by post hoc Bonferroni's multiple comparison test; F(2,69)=24.93, p<0.05). **p<0.05 compared to untreated WT mice; *p<0.05 compared to same genotype without treatment; n=20 WT no treatment; n=10 WT adult treatment; n=9 WT adolescent treatment; n=20 Fmr1 KO no treatment; n=10 Fmr1 KO adult treatment; n=9 Fmr1 KO adolescent treatment.