Fig. (2).

Ion channels in the cardiac fibroblasts. A. Summary of ion channels expressed in cardiac fibroblasts. The TRP channel mediated-Ca²⁺ and Ca²⁺ released from ER contribute to Ca²⁺ homeostasis, which regulates fibroblast function under normal and pathological conditions. Ca²⁺-entry from TRP channels will be largely influenced by the cell membrane potential which is controlled by various K⁺ channel activities. B. A representative recording of TRPM7 from cardiac fibroblasts.