TABLE 3.
Adverse Events From Systematic Inquiry in Overweight Outpatients With Schizophrenia or Schizoaffective Disorder Treated With Metformin or Placebo
| Adverse Event | Total (N=146)
|
Metformin Group (N=75)
|
Placebo Group (N=71)
|
p | |||
|---|---|---|---|---|---|---|---|
| N | % | N | % | N | % | ||
| Participants with ≥1 adverse event rated at moderate or severe intensity | 73 | 50.0 | 40 | 53.3 | 33 | 46.5 | 0.323 |
| Diarrhea | 37 | 25.3 | 25 | 33.3 | 12 | 16.9 | 0.018 |
| Headache | 28 | 19.2 | 11 | 14.7 | 17 | 23.9 | 0.181 |
| Muscle pain | 23 | 15.8 | 13 | 17.3 | 10 | 14.1 | 0.542 |
| Abdominal discomfort | 21 | 14.4 | 12 | 16.0 | 9 | 12.7 | 0.522 |
| Nausea | 20 | 13.7 | 12 | 16.0 | 8 | 11.3 | 0.370 |
| Weakness | 14 | 9.6 | 8 | 10.7 | 6 | 8.5 | 0.611 |
| Vomiting | 11 | 7.5 | 8 | 10.7 | 3 | 4.2 | 0.128 |