Figure 2.

Sleep/wake pattern and response to sleep deprivation in CNP-eGFP-L10a mice. A, Representative EEG recordings (frontal cortex) of a CNP-eGFP-L10a mouse during wake, NREM sleep, and REM sleep. B, Twenty-four hour sleep and wake patterns. In this and the next panels, white and black bars indicate the light and dark period, respectively. Values are mean ± SEM. C, Twenty-four hour wake, NREM sleep, and REM sleep EEG power density spectra (0–20 Hz) in CNP-eGFP-L10a mice (0.25 Hz frequency bin). D, Hypnogram, SWA time course, and motion activity in a representative CNP-eGFP-L10a mouse during baseline (BSL, top) and after 4 h of sleep deprivation (SD, bottom). E, F, Twenty-four hour time course of NREM duration and SWA for BSL and SD. *p < 0.05, significant increase during the first 2 h of recovery sleep after SD relative to BSL (paired t test).