Figure 4.
FUS/TLS accumulation at sites of UVA laser-induced damage is dependent on PARP-1. Parp-1+/+ (WT) and Parp-1−/−MEFs were transiently transfected with GFP-hFUS and microirradiated with a UVA laser. Representative images are presented, with quantification of GFP-FUS recruitment (mean ± SEM > 20 cells) plotted graphically (bottom).