Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Sep 25;42(1):163–180. doi: 10.1093/nar/gkt849

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 7. — p53 controls transcriptional repression of target genes by an indirect mechanism through CDE and CHR elements. High levels of p53 lead to transcriptional activation of its target p21^WAF1/CIP1. Inhibition of cyclin/CDK complex activity by p21^WAF1/CIP1 leads to hypophosphorylation of p130. Hypophosphorylated p130, together with E2F4/DP1, can then form a repressive complex with the MuvB core replacing B-Myb in the MMB complex. MMB only requires the CHR element. The complex of p107/p130 and E2F4/DP1 with the MuvB core is named DREAM. DREAM requires both elements, the CDE and the CHR, for binding and repression. This resembles the protein complex binding to promoters during quiescence. Expression of the viral oncoprotein HPV E7 impairs p21^WAF1/CIP1 function and blocks the pocket proteins p107/p130. Disruption of the DREAM complex then leads to derepression of cell cycle genes.