Table 3.
Overrepresentation of functional motifs in the predicted targets
| Bank | Name | Proteome | Targets | Overrepresentation | P-value | Function |
|---|---|---|---|---|---|---|
| Panther | PTHR19959:SF16 | 59 | 22 | 4.00 | 5.62E-09 | Kinesin |
| Fprint | PR00381 | 38 | 17 | 4.80 | 1.20E-08 | Kinesin light chain |
| Panther | PTHR19959 | 80 | 23 | 3.08 | 6.27E-07 | Structural constituent of cytoskeleton |
| Pfam | PF00931 | 31 | 12 | 4.15 | 1.09E-05 | NB-ARC domain |
| superfamily | SSF48452 | 231 | 41 | 1.90 | 4.23E-05 | TPR-like superfamily |
| Pfam | PF07721 | 21 | 9 | 4.59 | 5.43E-05 | Tetratricopeptide repeat |
| Smart | SM00028 | 124 | 26 | 2.25 | 6.43E-05 | Tetratricopeptide repeats |
| Prosite | PS50293 | 166 | 31 | 2.00 | 1.35E-04 | TPR repeat region |
| Pfam | PF00515 | 61 | 14 | 2.46 | 1.21E-03 | Tetratricopeptide repeat |
| Gene3D | G3DSA:1.25.40.10 | 326 | 45 | 1.48 | 4.94E-03 | TPR-like_helical |
| Pfam | PF08241 | 49 | 12 | 2.63 | 1.46E-03 | Methyltransferase |
| Panther | PTHR10108 | 33 | 9 | 2.92 | 2.55E-03 | Methyltransferase |
| Pfam | PF00066 | 31 | 9 | 3.11 | 1.58E-03 | LNR domain |
| Prosite | PS00120 | 13 | 5 | 4.12 | 4.76E-03 | Lipases, serine active site |
| Gene3D | G3DSA:2.160.20.10 | 98 | 17 | 1.86 | 8.82E-03 | Pectin lyase-like |
Motifs were grouped by similar function, and groups were sorted by ascending best P-value. ‘Proteome’ and ‘Targets’ show the number of proteins containing at least one instance of the motif in the whole genome and in the set of targets that we predicted in silico, respectively. The ‘Overrepresentation’ is the ratio of the two previous columns, each normalized to its respective total number of proteins in the set. The P-value is computed using the hypergeometric probability law.