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. 2013 Oct 1;42(1):e3. doi: 10.1093/nar/gkt878

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Direct measurement of genome replication in exponentially growing cells. (A) MFA as a proxy for replication time. Gray dots are the raw data points (in 1 kb windows), and the line shows the smoothed profile (left y-axis scale). Black dots show relative copy number from the (Illumina) sort-seq experiment (right y-axis scale). Open circles and vertical bars represent known replication origin locations. The full genome is shown in Supplementary Figure S10. (B) Comparison of MFA and median replication time (Trep).