Skip to main content
. Author manuscript; available in PMC: 2013 Dec 28.
Published in final edited form as: Anticancer Res. 2010 Apr;30(4):1279–1285.

Figure 1.

Figure 1

Normal function of cyclin D1a. Binding of cyclin D1a leads to phosphorylation of Rb and progression of the cell cycle into the G1 phase. Cyclin D1a is subsequently phosphorylated at Thr-286 by GSK-3β, leading to its nuclear export and degradation.