Table 3.

Summary accuracy measures for commercial and in-house tests

Measure of test accuracy	Pooled summary measurea (95% CI)	Test for heterogeneityb p value
All Commercial Tests [N = 14]
Sensitivity	0.62 (0.43, 0.77)	<0.001
Specificity	0.98 (0.96, 0.98)	0.12
Positive Likelihood Ratio (LR+)	25.4 (16.2, 40.0)	0.46
Negative likelihood Ratio (LR-)	0.40 (0.24, 0.67)	<0.001
Diagnostic odds ratio (DOR)	80.9 (34.4, 190.4)	0.09
Amplicor [N = 4]
Sensitivity	0.37(0.24, 0.52)	0.18
Specificity	0.99 (0.97, 1.0)	0.12
Positive Likelihood Ratio (LR+)	52.8 (11.8, 236.2)	0.14
Negative likelihood Ratio (LR-)	0.59 (0.37, 0.95)	0.20
Diagnostic odds ratio (DOR)	105.5 (15.1, 733.9)	0.10
LCx [N = 4]
Sensitivity	0.72 (0.54, 0.84)	0.12
Specificity	0.97 (0.95, 0.98)	0.53
Positive Likelihood Ratio (LR+)	25.6 (14.1, 46.4)	0.57
Negative likelihood Ratio (LR-)	0.32 (0.14, 0.68)	0.09
Diagnostic odds ratio (DOR)	93.2 (35.6, 243.7)	0.38
MTD [N = 6]
Sensitivity	0.77 (0.62, 0.88)	<0.001
Specificity	0.98 (0.96, 0.99)	0.66
Positive Likelihood Ratio (LR+)	17.4 (6.1, 49.7)	0.26
Negative likelihood Ratio (LR-)	0.31 (0.09, 1.03)	<0.001
Diagnostic odds ratio (DOR)	72.9 (9.9, 533.4)	0.03
In-house Tests [N = 26]
Sensitivity	0.71 (0.63, 0.78)	<0.001
Specificity	0.93 (0.88, 0.96)	<0.001
Positive Likelihood Ratio (LR+)	9.7 (5.7, 16.6)	<0.001
Negative likelihood Ratio (LR-)	0.32 (0.23, 0.43)	<0.001
Diagnostic odds ratio (DOR)	42.4 (22.2, 81.1)	<0.001

^aRandom effects model; ^bChi-square or Fisher's exact test for heterogeneity