Table 2.

Effect of antcin C on hepatic enzyme leakage, lipid peroxidation and glutathione depletion in AAPH-challenged mouse serum or liver tissues.

Parameters			AAPH (80 mg/Kg b.w)
			Antcin (mg/Kg b.w)			Silymarin (mg/Kg b.w)
	Control		25	50	100	200
Serum ALT (U/L)	4.1 ± 0.2	6.2 ± 2.3†	4.9 ± 1.4**	4.6 ± 0.1***	4.2 ± 0.1***	4.4 ± 0.2***
Serum AST (U/L)	3.7 ± 0.2	4.2 ± 0.5†	4.1 ± 0.7*	3.7 ± 0.2***	3.4 ± 0.2***	3.6 ± 0.1***
Hepatic GSH (mM)	97.2 ± 2.7	54.3 ± 9.9†	90.9 ± 7.9**	125.6 ± 8.4***	162.3 ± 18.8***	216.5 ± 38.2***
Serum GSH (mM)	7.5 ± 2.6	7.9 ± 7.3	21.1 ± 7.2**	49.9 ± 8.0***	92.6 ± 2.1***	81.9 ± 1.5***
Hepatic MDA (mM)	6.2 ± 1.1	20.9 ± 1.2†	13.3 ± 1.1*	10.7 ± 1.2**	6.4 ± 1.2***	6.6 ± 1.3***

Values represent the mean ± SD of three independent experiments. *P < 0.05, **P < 0.01, and ***P < 0.001 were considered significant for sample versus. AAPH. ^† P < 0.05 was considered significant for control versus AAPH.