Table 4.
Univariate and multivariate Cox regression analysis of prognostic factors of survival in HCC patients.
| Prognostic factor | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| P | Hazard ratio | 95% CI* | P | Hazard ratio | 95% CI* | |
| AFP ≥ 12,000 μg/L | <0.001 | 1.715 | 1.391–2.114 | 0.038 | 1.296 | 1.015–1.655 |
| Bilobar involvement | <0.001 | 1.651 | 1.356–2.010 | 0.019 | 1.414 | 1.059–1.886 |
| Multicentric tumor | 0.009 | 1.328 | 1.073–1.643 | 0.034 | 1.456 | 1.029–2.061 |
| Portal vein involvement | <0.001 | 2.129 | 1.711–2.649 | 0.002 | 1.507 | 1.159–1.960 |
| Distant metastases | <0.001 | 1.628 | 1.278–2.074 | NS | 1.222 | 0.921–1.620 |
| TNM stage (I&II/III&IV) | <0.001 | 1.964 | 1.508–2.558 | 0.047 | 1.546 | 1.006–2.377 |
| Child Pugh Grade | ||||||
| A | <0.001 | 1 | — | <0.001 | 1 | — |
| B | <0.001 | 1.932 | 1.561–2.390 | <0.001 | 1.766 | 1.393–2.239 |
| C | <0.001 | 2.509 | 1.867–3.372 | 0.004 | 1.665 | 1.177–2.354 |
| Any paraneoplastic syndrome | 0.025 | 0.782 | 0.630–0.970 | NS | 0.968 | 0.757–1.239 |
| Paraneoplastic hypercalcemia | 0.012 | 1.762 | 1.134–2.738 | NS | 1.013 | 0.621–1.653 |
| Paraneoplastic hypercholesterolemia | 0.013 | 1.335 | 1.062–1.677 | NS | 1.043 | 0.804–1.354 |
| Paraneoplastic erythrocytosis | NS | — | — | — | — | — |
*95% CI: 95% confidence interval, NS: not statistically significant (P > 0.05).