Table 3.
Reasons for therapy change by subsystem and period of analysis.
| % | Until 2000 | After 2001 | ||||||
|---|---|---|---|---|---|---|---|---|
| IMSS | SSA | INS | P valuea | IMSS | SSA | INS | P value | |
| Total changes | 133 | 6 | 404 | 476 | 148 | 547 | ||
| Optimizing a previous suboptimal regimen | 45.1 | 16.7 | 39.1 | 0.22 | 44.5 | 54.0 | 44.4 | 0.09 |
| Presumed viral failure | 33.8 | 50 | 35.9 | 0.67 | 31.9 | 24.3 | 36.9 | 0.01 |
| Toxicity | 12.8 | 16.7 | 21 | 0.03 | 14.1 | 9.4 | 14.8 | 0.11 |
| Deemed inadequate | 8.3 | 16.7 | 3.9 | 0.04 | 9.4 | 12.2 | 3.8 | 0.00 |
|
| ||||||||
| P-valueb | 0.04 | 0.00 | ||||||
aUntil 2000, the SSA was not included in comparisons for each reason due to the sample size.
bThe distribution of reasons for change between facilities in each period is significantly different.