Table 1.
Data on study patients.
| Baseline | Caduet | |
|---|---|---|
| Age (y) | 65 ± 2 | |
| Sex (male: %) | 52 | |
| Diabetes (%) | 31 | |
| Serum creatinine (mg/dL) | 1.43 ± 0.07 | 1.44 ± 0.08 |
| Urinary protein (g/gCr) | 0.99 ± 0.12 | 0.96 ± 0.11 |
| Blood pressure (mmHg) | 133 ± 2/74 ± 1 | 135 ± 2/74 ± 1 |
| Pulse rate (bpm) | 75 ± 2 | 74 ± 2 |
| Total cholesterol (mg/dL) | 196 ± 3 | 187 ± 2* |
| Triglycerides (mg/dL) | 138 ± 8 | 131 ± 7* |
| HDL-C (mg/dL) | 52 ± 2 | 55 ± 2* |
| High sensitive CRP (mg/L) | 1.2 ± 0.1 | 1.1 ± 0.1 |
| Central blood pressure (mmHg) | 124 ± 3 | 122 ± 3 |
| Flow-mediated dilation (%) | 2.3 ± 0.2 | 2.7 ± 0.2* |
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| Medications | ||
|
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| Angiotensin receptor blockers | 17 patients | |
| Direct renin inhibitors | 12 patients | |
| Converting enzyme inhibitor | 4 patients | |
| Diuretics | 20 patients | |
| Beta blockers | 8 patients | |
| Alpha blockers | 7 patients | |
| CNS-acting antihypertensives | 3 patients | |
Cr: creatinine; bpm: beats per minute; CRP: C-reactive protein; and HDL-C: high density lipoprotein cholesterol. *Indicates significant difference from respective baseline value.