Fig. 4.

Effects of carbachol spontaneous electrical activities in cultured ICCs from mouse urinary bladder. Carbachol (10^-8 M) produced depolarization of the resting membrane with an increase of the frequency of spontaneous spike potentials in individual type (A). In the bursting type, carbachol produced depolarization of the resting membrane with a decrease of the frequency of spontaneous spike potentials (B). Atropine (10^-6 M) blocked the carbachol-induced effects on spontaneous spike potentials in both individual (C) and bursting (D) types. Dotted lines indicate resting level of membrane potentials. CCh: carbachol.