Table 2.

VBM significant results

Region	Left/ Right	p-value for cluster*	volume of cluster (mm3)	Peak MNI coordinates			Peak T-value
Patients post-CBT > patients pre-CBT
PPC (inferior)	L	0.008	1195	−56	−58	18	8.50
				−54	−54	8	5.69
				−52	−68	15	4.65
Premotor/M1/S1¥	R	0.040	2413	66	9	15	7.43
				69	−9	28	6.97
				68	−20	38	6.91
Hippocampus	R	0.027	793	28	−42	−12	7.16
				33	−52	−3	5.17
				27	−52	−12	4.61
DLPFC	R	0.001	8414	26	32	56	7.10
				16	36	52	6.32
				21	45	44	6.25
S1	L	0.013	1225	−45	−32	62	7.05
				−39	−39	62	5.10
				−33	−40	56	4.17
sACC/OFC¥	L	0.016	996	−8	20	−18	6.92
				−15	14	−22	5.75
PPC (superior)	L	0.006	2133	−30	−56	60	6.35
				−34	−60	42	5.81
				−34	−51	52	5.68
Inferior temporal	L	0.040	1232	−54	−60	−18	6.17
				−46	−78	−12	4.65
				−60	−54	−12	4.61
S2/M1	L	0.009	2400	−60	−26	14	6.12
				−66	−20	33	5.79
				−60	−30	40	5.03
DLPFC¥	L	0.047	2008	−26	22	51	5.70
				−27	−3	64	5.38
				−26	15	57	5.32
Patients post-CBT < patients pre-CBT
SMA/pre-SMA	R	0.002	2204	15	30	42	6.96
				16	14	54	6.72
				15	21	50	6.13
DECREASED pain catastrophizing correlated with increased GMD
S2/S1/PPC	R	0.0001	12477	54	−18	30	8.70
				62	−34	38	7.53
				46	−26	22	7.32
ACC	L	0.0030	2373	−4	52	0	6.45
				−3	50	22	6.41
				−6	48	10	5.81
DLPFC	L	0.0005	5755	−52	14	22	6.28
				−42	18	46	6.23
				−46	12	38	6.20
IFG	L	0.0060	1796	−56	6	4	5.77
				−54	22	−3	5.72
				−60	−8	6	5.65
INCREASED pain catastrophizing correlated with increased GMD
Hippocampus¥	R	0.0040	1438	24	−38	−3	9.12
				28	−42	−9	6.57
DLPFC¥	R	0.0200	824	38	40	16	7.57
				42	34	24	5.75
INCREASED ability to control pain correlated with increased GMD
Motor cortex¥	R	0.0170	1137	48	−8	48	7.14
				46	3	45	5.39
				52	−4	33	4.89
DECREASED physical health (SF-36 subscale) correlated with increased GMD
Middle temporal gyrus, inferior parietal¥	R	0.0040	824	39	−54	14	9.30
				40	−58	4	5.86
				34	−66	18	4.10

^*FWE corrected at cluster level, non-stationarity corrected

^¥ cluster is not significant when a covariate for pain type is included.

ACC, anterior cingulate cortex; DLPFC, dorsolateral prefrontal cortex; IFG, inferior frontal gyrus; M1, primary motor cortex; PPC, posterior parietal cortex; S1, primary somatosensory cortex; S2, second somatosensory cortex; sACC/OFC, subgenual ACC/oribotofrontal cortex; SMA, supplementary motor area.