Table 2.
Summary of EDC Effects on Estrous Cycle Characteristics
| Estrous Cycle Characteristics, % | Females |
||
|---|---|---|---|
| DMSO | EB | A1221 | |
| Regular cycles (P90 females only) | 85.0 | 63.2a | 85.0 |
| Animals with PD (all cycling females) | 5.1 | 13.5a | 6.7 |
| Cycles that skip proestrus (all cycling females) | 20.5 | 40.5a | 28.9 |
| First 3 cycles regular (all cycling females) | 89.7 | 83.8a | 84.4 |
| At least 2 strings of >5 days of C/L vaginal smears | 10.3 | 21.6a | 17.8b |
Abbreviations: AGD, anogenital distance; C, cornified smear; L, leukocytic smear; PD, persistent diestrus; d, days of age. Data shown are means (± SEM).
a
Significant effect (P < .05).
b
Trend (.05 < P < .1) compared to corresponding DMSO group.