Figure 6.

Proposed model for the contribution of KISS1R trafficking to prolonged Ca²⁺ signaling. Kisspeptin binds to KISS1R to stimulate a rapid acute-phase increase in [Ca²⁺]_i as well as rapid KISS1R internalization. The internalized ligand undergoes rapid degradation and is released extracellularly, whereas the KISS1R undergoes a much slower degradation. In addition to KISS1R recycling, there is also dynamic recruitment of KISS1R from intracellular pools to the cell surface that maintains sufficient cell surface KISS1R to bind with exogenous kisspeptin and maintain prolonged Ca²⁺ signaling. ER, endoplasmic reticulum.