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. 2013 Dec 30;7:44. doi: 10.3389/fnana.2013.00044

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Copyright © 2013 Fang, He, Zhang, Hu, Yang, Jiang and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Treatment with CNTF or C16 reduced demyelination in the spinal cord and cerebral cortex, as revealed by MBP immunostaining, counterstained with hematoxylin (coronal sections of brain motor cortex), Bar = 100 μm. At week 2 post-immunization, normal control group (A), vehicle-treated EAE rats (B), CNTF-treated EAE rats (C), C16-treated EAE rats (D), and C16+CNTF-treated rats (E). (F,G) Treatment with CNTF or C16 prevented demyelination at week 2 (F) and week 8 (G) post-immunization. ^aP < 0.05 versus the normal control; ^bP < 0.05 versus vehicle-treated EAE rats; ^cP < 0.05 versus CNTF-treated EAE rats; ^dP < 0.05 versus C16-treated EAE rats.