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. 2013 Dec 30;4:165. doi: 10.3389/fphar.2013.00165

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Copyright © 2013 Steiner, Sciarretta, Pasquali and Jenck.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Glucose homeostasis in week 17. (A) Oral glucose tolerance test (oGTT) performed on overnight fasted SC and CAF fed rats treated with Veh or ACT. Whole blood glucose was measured before (0 min) and at the indicated time points after the oral (po) administration of 2 mg/kg glucose (arrow). ^*p < 0.05 vs. CAF-Veh at the indicated time point by post-hoc test following ANOVA. Mean ± s.e.m. (n = 8–11) per group. Due to an incomplete blood sample set, data from one SC-Veh and one CAF-Veh rat had to be omitted because of repeated measures within subjects analyses. (B) AUC calculated individually for each rat. ^*p < 0.05 by t-test. The CAF-ACT group was statistically not different from the CAF-Veh group. (SC, standard chow; CAF, cafeteria diet; Veh, vehicle; ACT, ACT-335827; po, per os; AUC, area under the curve; ns, not significant).