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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2013 Nov 5;274(1):10.1016/j.taap.2013.10.022. doi: 10.1016/j.taap.2013.10.022

FIGURE 3. Treatment with I3C or DIM decreases pro-inflammatory cytokine release after SEB stimulation.

FIGURE 3

Splenocytes from C57BL/6 mice were cultured for 24 hours with or without 1ug/ml of SEB, in the absence or presence of I3C or DIM (100uM). Supernatants were collected after 24 hours and ELISA assay was used to detect IL-2, IL-6, TNF-α, and IFN-γ. Statistical significance (p-value <0.05) was determined using GraphPad Prism analysis software with one-way ANOVA and Tukey’s multiple comparsion test (+ indicates significance compared to Vehicle group, and * indicates significance compared to SEB+Vehicle).