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. 2013 Nov 13;3:43. doi: 10.1186/2045-3701-3-43

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Copyright © 2013 Luu et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Phylogenetic tree of HALs from different species as shown in Figure1suggests that the two HAL genes were duplicated after the separation of mammals and amphibians but prior to the separation of Xenopus laevis and Xenopus tropicalis or that mammals lost the HAL1 gene during evolution.