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S-phase fraction in ardipusilloside I-treated and control cells. (A) Control. (B) 5.0 μg/ml ardipusilloside I. (C) 10.0 μg/ml ardipusilloside I. (D) A significant fraction of cells were found in S-phase when treated with 5.0 μg/ml or 10.0 μg/ml ardipusilloside I for 48 h compared with control cells. *P = 0.0026, **P = 0.0002.
