Table 2.

Summary of the trials examined T

Study year	Intervention	Bisphosphonate acid administration	Combination therapy	Duration (y)	No. patients per arm	Follow-up (months)
ABCSG-12 (2011) [15]	Zoledronic acid Observation	4 mg IV every 6 mos	Goserelin and Tamoxifen or Anastrozole	3	900	62
					903
AZURE (2011) [14]	Zoledronic acid Observation	4 mg IV every 4 wks × 6, then 3 mos × 8 and 6 mos × 5	Standard treatment	5	1681	59
					1678
E-ZO-FAST (2009) [20]	Upfront zol	4 mg IV every 6 mos	Letrozol	5	263	36
	Delayed zol				264
Z-FAST (2012) [17]	Upfront zol	4 mg IV every 6 mos	Letrozol	5	300	61
	Delayed zol				300
ZO-FAST (2013) [16]	Upfront zol	4 mg IV every 6 mos	Letrozol	5	532	60
	Delayed zol				533
Talahashi et al., (2013) [21]	Upfront zol	4 mg IV every 6 mos	Letrozol	1	94	36
	Delayed zol				95
Leal et al., (2010) [19]	Zoledronic acid Observation	4 mg IV every 3 mos	Standard treatment	1	36	96
					32
Aft et al., (2012) [18]	Zoledronic acid Observation	4 mg IV every 3 wks	Neoadjuvant chemotherapy		60	61.9
					59