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Specific cellular targets of JNK1 and JNK2 in different types of cancer. A diagram showing the different targets regulated by the individual JNK proteins. Distinct functions of JNK1 and JNK2 in various cancers appear through differing regulation of specific substrates and/or downstream effectors. The development of inhibitors that target specific downstream effectors of the individual JNK proteins would provide unique opportunities for therapeutic interventions.
