Figure 3.
Rescue of human failing ventricular cardiomyocyte contraction and relaxation by in vitro Ad.SERCA2a gene transfer. Analysis of % shortening (above) and Fura-2-reported Ca2+ transients (below) reveals lower amplitude, slower contractions and Ca2+ transients in heart failure cells. This was rescued by SERCA2a gene transfer via an adenoviral vector. Reproduced with permission from Wolters Kluwer Health: Circulation [del Monte et al. (1999)]. © 1999.