Skip to main content
. 2013 Dec 10;171(1):38–54. doi: 10.1111/bph.12472

Figure 5.

Figure 5

Modulation of alternans-mediated arrhythmia by SERCA2a gene transfer. (A) Optical mapping of a Langendorff-perfused heart failure (HF) heart reveals marked action potential duration (APD) alternans with subsequent induction of ventricular fibrillation (VF). In a HF heart treated with SERCA2a gene therapy (HF + AAV9.SERCA2a), such alternans does not occur despite an even shorter basic cycle length. (B) Graph of increasing threshold for alternans and decreasing inducibility of VT/VF in the presence of higher SERCA2a expression from lowest (HF) to highest (SERCA2a-treated controls – control + Ad.SERCA). Reproduced with permission from Wolters Kluwer Health: Circulation [Cutler et al. (2012b)]. © 2012.