Figure 2.

Changes in the level of CTX in serum samples from normal, OVX and treatment groups during the experimental period. Methionine at doses 100, 250 and 500 mg·kg⁻¹ body wt was administered in drinking water for 10 weeks. Alendronate (200 μg·kg⁻¹ body wt) was administered p.o. to OVX rats at an interval of 5 days for 1 month. For combination therapy, rats were administered alendronate (100 μg·kg⁻¹ body wt) and methionine (250 mg·kg⁻¹ body wt). Both treatments were performed 6 h apart. CTX levels in serum were measured by immunoassay. Values are mean ± SEM; n = 4. *P < 0.05 compared with normal rat. **P < 0.05 compared with OVX rat. ***P < 0.05 compared with alendronate (200 μg·kg⁻¹ body wt)-treated OVX rats.