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. 2013 Dec 10;171(1):107–121. doi: 10.1111/bph.12434

Figure 3.

Figure 3

Changes in the activity of TRAP5b in serum of normal, OVX and treatment groups. Methionine at doses 100, 250 and 500 mg·kg−1 body wt was administered in drinking water for 10 weeks. Alendronate (200 μg·kg−1 body wt) was administered p.o. to OVX rats at an interval of 5 days for 1 month. For combination therapy, rats were administered alendronate (100 μg·kg−1 body wt) and methionine (250 mg·kg−1 body wt). Both treatments were performed 6 h apart. TRAP5b activity in serum was measured by immunoassay. Values are mean ± SEM; n = 4. *P < 0.05 compared with normal rat. **P < 0.05 compared with OVX rat. ***P < 0.05 compared with alendronate (200 μg·kg−1 body wt)-treated OVX rats.