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CIH blocked Ft1-induced platelet aggregation and calcium release. (A) Ft1 potentiated the coagulant effect of ADP (4.5 μM) when used at 1, 100 and 200 μM. (B) CIH (5 μM) inhibited the platelet aggregatory effects of ADP (50 μM) and Ft1 (200 μM) respectively. (C) CIH inhibited ADP (50 μM) and Ft1 (56.4 μM) evoked intracellular calcium accumulation within platelets (***P < 0.001, n = 6, mean ± SD).
