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Ft1 enhanced the intracellular accumulation of Ca2+ in HEK293 cells overexpressing rat P2Y12 receptors. Both ADP (50 μM) and Ft1 (56.4 μM) evoked a significant peak in the Ca2+ levels in the cells (transfected with P2Y12 receptor plasmids) after 40 s, and this effect was blocked by TIC (5 μM). In contrast, in HEK293 cells transfected with empty plasmids, neither ADP nor Ft1, denoted as ADP+Emp and Ft1+Emp, respectively, had a significant effect on intracellular calcium accumulation.
