Table 2.
Response of a panel of breast carcinoma cell lines exposed to dasatinib under aerobic and hypoxic conditions for 96 h
| Cell line | Aerobic IC50 (μM) | Hypoxic IC50 (μM) | HCR |
|---|---|---|---|
| MCF7 | 0.18 ± 0.11 | 0.012 ± 0.007++ | 15.00 |
| MDA-MB-231 | 0.033 ± 0.009 | 0.006 ± 0.004++ | 5.50 |
| MDA-MB-468 | 16.58 ± 2.47 | 3.17 ± 1.70++ | 5.23 |
| MDA-MB-453 | 8.27 ± 3.36 | 5.97 ± 1.45 | 1.38 |
| Hs578T | 0.044 ± 0.016 | 0.048 ± 0.013 | 0.91 |
| T47D | 10.45 ± 2.98 | 16.85 ± 2.53+ | 0.62 |
| BT20 | 1.14 ± 0.59 | 9.63 ± 4.06++ | 0.12 |
Each value represents the mean ± SD of at least three independent experiments. Statistical analysis comparing response under hypoxia to aerobic conditions was performed using Student's t-test and P-values of <0.05 and 0.01 are represented as + and ++ respectively.