Table 3.

Studies included in meta-analyses

					Cases		Controls
Gene	Author	Ref number	Country	Publication year	# Cases	MAF	# Controls	MAF
PTPN22 C1858T	Seldin et al.	[7]	Finland	2005	230	0.18	1400	0.15
	Hinks et al.	[5]	UK	2005	661	0.15	595	0.10
	Cinek et al.	[18]	Czech/Azeri	2007	130	0.21	400	0.10
	Pazar et al.	[19]	Hungary	2008	150	0.09	200	0.08
	Thompson et al.	[4]	USA	2010	809	0.14	531	0.09
	Ellis	[29]	Australian	2013	324	0.10	568	0.07
	Viken et al.	[6]	Norway	2005	320	0.16	555	0.12
	Kaalla et al.	Present	USA		637	0.13	733	0.11
MIF G-173C	Donn et al.*	[[16]]	UK	2002	526	0.19	259	0.11
	Miterski et al.	[9]	Germany	2004	150	0.24	390	0.21
	Berdeli et al.	[13]	Turkey	2006	67	0.13	153	0.10
	Kaalla et al.	Present	USA		639	0.18	742	0.17
TNFA G-238A	Ozen et al.*	[[22]]	Turkey	2002	51	0.22	93	0.27
	Ozen et al.*	[[22]]	Czech	2002	159	0.23	100	0.17
	Zeggini et al.	[23]	UK	2002	137	0.03	76	0.09
	Miterski et al.	[9]	Germany	2004	130	0.02	375	0.03
	Modesto et al.	[20]	Spain	2005	55	0.07	59	0.09
	Schmeling et al.	[11]	Germany	2006	228	0.03	196	0.03
	Kaalla et al.	Present	USA		639	0.04	749	0.06
TNFA G-308A	Ozen et al.*	[22]	Turkey	2002	51	0.25	93	0.31
	Ozen et al.*	[22]	Czech	2002	159	0.27	100	0.16
	Zeggini et al.	[23]	UK	2002	138	0.24	75	0.13
	Miterski et al.	[9]	Germany	2004	122	0.17	312	0.16
	Modesto et al.	[20]	Spain	2005	55	0.13	59	0.12
	Schubert et al.	[12]	Germany	2006	86	0.15	270	0.15
	Schmeling et al.	[11]	Germany	2006	228	0.14	196	0.17
	Mourao et al.	[21]	Portugal	2009	115	0.12	118	0.11
	Kaalla et al.	Present	USA		629	0.14	729	0.17

*Bolded studies were removed from analysis due to evidence for heterogeneity, using Cochran’s Q test (p < 0.10 threshold).